منابع مشابه
Hepatitis C virus and hepatocarcinogenesis
Hepatitis C virus (HCV) is an RNA virus that is unable to integrate into the host genome. However, its proteins interact with various host proteins and induce host responses. The oncogenic process of HCV infection is slow and insidious and probably requires multiple steps of genetic and epigenetic alterations, the activation of cellular oncogenes, the inactivation of tumor suppressor genes, and...
متن کاملHepatitis B virus and hepatocarcinogenesis.
Hepatitis B viral (HBV) infection is the commonest cause of hepatocellular carcinoma. HBV DNA is the most important predictor of hepatocarcinogenesis in HB surface antigen positive patients. We reviewed the mechanism of hepatocarcinogenesis on molecular level with a special emphasis on the role of X-protein. Hepatitis B X-protein communicates with host targets and disturbs cellular functions in...
متن کاملHepatocarcinogenesis in viral Hepatitis B infection: the role of HBx and p53.
Infection of Hepatitis B Virus (HBV) is a risk factor of chronic active hepatitis (CAH), hepatic cirrhosis and hepatocellular carcinoma (HCC). Infection of HBV may develop to HCC without antecedent hepatic cirrhosis. Pathogenesis of HBV causing malignant changes has not been fully understood. HBx, a protein of HBV, is an activator of transcription process involved in hepatocarcinogenesis. Most ...
متن کاملViral Hepatitis 1 VIRAL HEPATITIS
1. Distinguish among viral hepatitis A, B, C, D, and E’s virology, epidemiology, and serological response to infection and clinical manifestation. 2. Design a prophylactic and therapeutic plan identifying the risk factors associated with the transmission of viral hepatitis A, B, C, D, or E in a clinical situation. 3. Develop an appropriate prophylactic regimen for preventing viral hepatitis A, ...
متن کاملHepatitis B virus gene mutations and hepatocarcinogenesis.
Chronic hepatitis B virus (HBV) infection has long been the most common cause of hepatocellular carcinoma (HCC). However, some aspects of the pathogenesis of HBV infection and genesis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) are still inconclusive. An increasing number of published studies indicate that hepatitis B virus mutations are associated with risk of HCC. These ...
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ژورنال
عنوان ژورنال: SEIBUTSU BUTSURI KAGAKU
سال: 1996
ISSN: 0031-9082,1349-9785
DOI: 10.2198/sbk.40.289